Publications

An Emergent Role for Mitochondrial Bioenergetics in the Action of Snake Venom Toxins on Cancer Cells. Urra FA, Vivas-Ruiz DE, Sanchez EF, Araya-Maturana R. Front Oncol. 2022;12:938749. doi: 10.3389/fonc.2022.938749.

Description of the antipredatory head-wobble behaviour in Chilean rear-fanged snakes Tachymenis peruviana Wiegmann, 1835 and Tachymenis chilensis coronellina Werner, 1898 (Serpentes, Dipsadidae). Reyes-Olivares C, Vera-Quispe A, Zúñiga A, Urra FA. Herpetozoa. 2022; 35: 155-158. https://doi.org/10.3897/herpetozoa.35.e84842

A paraguayan toad Rhinella schneideri preparation based on Mbya tradition increases mitochondrial bioenergetics with migrastatic effects dependent on AMPK in breast cancer cells. Schmeda-Hirschmann G, Burgos-Edwards A, Rojas de Arias A, López-Torres C, Palominos C, Fuentes-Retamal S, Herrera Y, Dubois-Camacho K, Urra FA. J Ethnopharmacol. 2022;294:115344. doi: 10.1016/j.jep.2022.115344.

Functional, immunological characterization, and anticancer activity of BaMtx: A new Lys49- PLA2 homologue isolated from the venom of Peruvian Bothrops atrox snake (Serpentes: Viperidae). Proleón A, Torrejón D, Urra FA, Lazo F, López-Torres C, Fuentes-Retamal S, Quispe E, Bautista L, Agurto A, Gavilan RG, Sandoval GA, Rodríguez E, Sánchez EF, Yarlequé A, Vivas-Ruiz DE. Int J Biol Macromol. 2022;206:990-1002.

Putting the brakes on tumorigenesis with snake venom toxins: New molecular insights for cancer drug discovery. Urra FA, Araya-Maturana R. Semin Cancer Biol. 2022;80:195-204.

Extracellular matrix signals as drivers of mitochondrial bioenergetics and metabolic plasticity of cancer cells during metastasis. Urra FA, Fuentes-Retamal S, Palominos C, Rodríguez-Lucart YA, López-Torres C, Araya-Maturana R. Front Cell Dev Biol. 2021;9:751301. doi: 10.3389/fcell.2021.751301.

FRI-1 is an anti-cancer isoquinolinequinone that inhibits the mitochondrial bioenergetics and blocks metabolic shifts by redox disruption in breast cancer cells. Córdova-Delgado M, Fuentes-Retamal S, Palominos C, López-Torres C, Guzmán-Rivera D, Ramírez-Rodríguez O, Araya-Maturana R, Urra FA. Antioxidants (Basel). 2021 Oct 14;10(10):1618. doi: 10.3390/antiox10101618.

First reports of envenoming by South American water snakes Helicops angulatus and Hydrops triangularis from Bolivian Amazon: A one-year prospective study of non-front-fanged colubroid snakebites. Villca-Corani H, Nieto-Ariza B, León R, Rocabado JA, Chippaux JP, Urra FA. Toxicon. 2021;202:53-59. doi: 10.1016/j.toxicon.2021.09.003.

Recent advances in molecular mechanisms of anticancer natural products that target mitochondrial bioenergetics, Urra, F. A., Fuentes-Retamal, S., Palominos, C., and Araya-Maturana, R. In Studies in Natural Products Chemistry, ed. A. Atta-ur-Rahman (Amsterdam: Elsevier), 2021, 1–41.

Leucism and albinism in the rear-fanged snakes Tachymenis chilensis chilensis (Schlegel, 1837) and Tachymenis chilensis coronellina Werner, 1898 (Serpentes, Dipsadidae). Urra FA, Zúñiga A, Melero N, Reyes N, Herrera Y, Miranda-Calle AB, Ortiz JC. Herpetozoa 2021, 34: 125-129. https://doi.org/10.3897/herpetozoa.34.e63423

Zañartu N, Urra FA. Nocturnal activity of a rear-fanged Chilean snake, Tachymenis chilensis coronellina (Serpentes: Dipsadidae). Herpetology Notes 14: 1365-1366.

  • Cancer cells with defective oxidative phosphorylation require endoplasmic reticulum-to-mitochondria Ca 2+ transfer for survival. Cardenas C, Lovy A, Silva-Pavez E, Urra F, Mizzoni C, Ahumada-Castro U, Bustos G, Jaňa F, Cruz P, Farias P, Mendoza E, Huerta H, Murgas P, Hunter M, Rios M, Cerda O, Georgakoudi I, Zakarian A, Molgó J, Foskett JK. Sci Signal. 2020 Jul 14;13(640):eaay1212.
  • An acylhydroquinone derivative produces OXPHOS uncoupling and sensitization to BH3 mimetic ABT-199 (Venetoclax) in human promyelocytic leukemia cells. Donoso-Bustamante, V., Borrego, E.A., Schiaffino-Bustamante, Y., Gutiérrez, D.A., Millas-Vargas, J. P., Fuentes-Retamal, S., Correa, P., Carrillo, I., Aguilera, R.J., Miranda, D., Chávez-Báez, I., Pulgar, R., Urra, F.A., Varela-Ramírez, A., & Araya-Maturana, R.Bioorganic chemistry, 100, 103935. https://doi.org/10.1016/j.bioorg.2020.103935
  • Fibrinogen-clotting enzyme, pictobin, from Bothrops pictus snake venom. Structural and functional characterization. International journal of biological macromolecules, 153, 779–795. Vivas-Ruiz, D.E., Sandoval, G.A., Gonzalez-Kozlova, E., Zarria-Romero, J., Lazo, F., Rodríguez, E., Magalhães, H., Chávez-Olortegui, C., Oliveira, L.S., Alvarenga, V.G., Urra, F.A., Toledo, J., Yarlequé, A., Eble, J.A., & Sanchez, E.F.
  • Synthesis of antiplatelet ortho-carbonyl hydroquinones with differential action on platelet aggregation stimulated by collagen or TRAP-6. European journal of medicinal chemistry, 192, 112187. Méndez, D., Urra, F.A., Millas-Vargas, J.P., Alarcón, M., Rodríguez-Lavado, J., Palomo, I., Trostchansky, A., Araya-Maturana, R., & Fuentes, E.
  • Complex Mitochondrial Dysfunction Induced by TPP+-Gentisic Acid and Mitochondrial Translation Inhibition by Doxycycline Evokes Synergistic Lethality in Breast Cancer Cells. Fuentes-Retamal, S., Sandoval-Acuña, C., Peredo-Silva, L., Guzmán-Rivera, D., Pavani, M., Torrealba, N., Truksa, J., Castro-Castillo, V., Catalán, M., Kemmerling, U., Urra, F.A., & Ferreira, J. (2020). Cells, 9(2), 407. https://doi.org/10.3390/cells9020407
  • The Parotoid Gland Secretion from Peruvian Toad Rhinella horribilis (Wiegmann, 1833): Chemical Composition and Effect on the Proliferation and Migration of Lung Cancer Cells. Schmeda-Hirschmann G, de Andrade JP, Soto-Vasquez MR, Alvarado-García PAA, Palominos C, Fuentes-Retamal S, Mellado M, Correa P, Urra FA. Toxins (Basel). 2020, 22;12(9):608. doi: 10.3390/toxins12090608.
  • Urra FA, Zúñiga A, Miranda-Calle AB, Melero N. First record of the invasive Gecko, Lepidodactylus lugubris Duméril & Bibron 1836 (Squamata, Gekkonidae), in mainland Chile. Herpetozoa. 2020 (33):125-129.
  • Philodryas (Serpentes: Dipsadidae) Envenomation, a Neglected Issue in Chile. Toxins, 11(12), 697. https://doi.org/10.3390/toxins11120697. Urra, F.A., Miranda-Calle, A. B., & Araya-Maturana, R.
  • Complex I and II are required for normal mitochondrial Ca2+ homeostasis. Mitochondrion, 49, 73–82. https://doi.org/10.1016/j.mito.2019.07.004. Jaña, F., Bustos, G., Rivas, J., Cruz, P., Urra, F., Basualto-Alarcón, C., Sagredo, E., Ríos, M., Lovy, A., Dong, Z., Cerda, O., Madesh, M., & Cárdenas, C.
  • Regulation of mitochondrial function as a promising target in platelet activation-related diseases. Free Radic Biol Med. 2019. 136:172-182. doi: 10.1016/j.freeradbiomed.2019.01.007. Fuentes E, Araya-Maturana R, Urra FA.
  • Cañas, J & Urra, FA; 2019. Philodryas chamissonis (Chilean Green Racer) Nocturnal activity. Herpetological Review 50 (3): 600.
  • Cabeza O, Vargas E, Ibarra C, Urra F. 2019. Observations on reproduction in captivity of the endemic long-tailed snake Philodryas chamissonis (Wiegmann, 1835) (Reptilia, Squamata, Dipsadidae) from Chile. Herpetozoa 32: 203-209
  • Contreras, José M.; Felix A. Urra, Nicolás A. Rojas-Porras 2019. First record of Pompilocalus sp. ROIG ALSINA, 1989 (Hymenoptera: Pompilidae) preying on Tachymenis chilensis coronellina (WERNER, 1898)(Serpentes: Dipsadidae) from Central Chile. Herpetology Notes 12: 931-932
  • Urra FA, Muñoz F, Córdova-Delgado M, Ramírez MP, Peña-Ahumada B, Rios M, Cruz P, Ahumada-Castro U, Bustos G, Silva-Pavez E, Pulgar R, Morales D, Varela D, Millas-Vargas JP, Retamal E, Ramírez-Rodríguez O, Pessoa-Mahana H, Pavani M, Ferreira J, Cárdenas C, Araya-Maturana RFR58P1a; a new uncoupler of OXPHOS that inhibits migration in triple-negative breast cancer cells via Sirt1/AMPK/β1-integrin pathway. Sci Rep. 2018;8(1):13190.
  • Troncoso-Palacios J, Esquerré D, Urra FA, Díaz HA, Castro-Pastene C and Ruiz MS. The True Identity of the New World Iguanid Lizard Liolaemus chillanensis Müller and Hellmich 1932 (Iguania: Liolaemidae) and Description of a New Species in the Liolaemus elongatus Group. Zoological Studies 57: 21 (2018). doi:10.6620/ZS.2018.57-21.
  • Urra F, Muñoz F, Lovy A, Cárdenas C. The mitochondrial complex(I)ty of cancer. Front. Oncol. 2017; 7: 118. doi 10.3389/fonc.2017.00118.
  • Urra F, Diaz HA, Werning H, Eisenberg T, Troncoso-Palacios J. Phymaturus vociferator Pincheira-Donoso, 2004 (Squamata: Liolaemidae): distribution extension and geographic distribution map. Checklist Journal. 2017; 13 (3):2137.
  • Schmeda-Hirschmann G, Gomez CV, Rojas de Arias A, Burgos-Edwards A, Alfonso J, Rolon M, Brusquetti F, Netto F, Urra FA, Cárdenas C. The Paraguayan Rhinella toad venom: Implications in the traditional medicine and proliferation of breast cancer cells. J Ethnopharmacol. 2017; 199:106-118. doi: 10.1016/j.jep.2017.01.047.
  • Urra FA, Araya-Maturana R. Targeting Metastasis with Snake Toxins: Molecular Mechanisms. Toxins (Basel). 2017, 9(12). pii: E390. doi: 10.3390/toxins9120390
  • Schmeda-Hirschmann G, Quispe C, Arana GV, Theoduloz C, Urra FA, Cárdenas C. Antiproliferative activity and chemical composition of the venom from the Amazonian toad Rhinella marina (Anura: Bufonidae). Toxicon. 2016. 121:119-129. doi: 10.1016/j.toxicon.2016.09.004.
  • Urra FA, Weiss-López B, Araya-Maturana R. Determinants of Anti-Cancer Effect of Mitochondrial Electron Transport Chain Inhibitors: Bioenergetic Profile and Metabolic Flexibility of Cancer Cells. Curr Pharm Des. 2016;22(39):5998-6008.
  • Urra FA, Córdova-Delgado M, Lapier M, Orellana-Manzano A, Acevedo-Arévalo L, Pessoa-Mahana H, González-Vivanco JM, Martínez-Cifuentes M, Ramírez-Rodríguez O, Millas-Vargas JP, Weiss-López B, Pavani M, Ferreira J, Araya-Maturana R. Small structural changes on a hydroquinone scaffold determine the complex  I inhibition or uncoupling of tumoral oxidative phosphorylation. Toxicol Appl Pharmacol. 2016;291:46-57.
  • Cárdenas C, Müller M, McNeal , Lovy , Jaňa F, Bustos , Urra F, Smith N, Molgó J, Diehl JA, Ridky TW, Foskett JK. Selective Vulnerability of Cancer Cells by Inhibition of Ca(2+) Transfer from Endoplasmic Reticulum to Mitochondria. Cell Rep. 2016;14(10):2313-24.
  • Schmeda-Hirschmann G, Quispe C, Arana GV, Theoduloz C, Urra FA, Cárdenas C. Antiproliferative activity and chemical composition of the venom from the Amazonian toad Rhinella marina (Anura: Bufonidae). Toxicon. 2016. 121:119-129. doi: 10.1016/j.toxicon.2016.09.004.
  • Urra FA, Weiss-López B, Araya-Maturana R. Determinants of Anti-Cancer Effect of Mitochondrial Electron Transport Chain Inhibitors: Bioenergetic Profile and Metabolic Flexibility of Cancer Cells. Curr Pharm Des. 2016;22(39):5998-6008.
  • Urra FA, Córdova-Delgado M, Lapier M, Orellana-Manzano A, Acevedo-Arévalo L, Pessoa-Mahana H, González-Vivanco JM, Martínez-Cifuentes M, Ramírez-Rodríguez O, Millas-Vargas JP, Weiss-López B, Pavani M, Ferreira J, Araya-Maturana R. Small structural changes on a hydroquinone scaffold determine the complex  I inhibition or uncoupling of tumoral oxidative phosphorylation. Toxicol Appl Pharmacol. 2016;291:46-57.
  • Cárdenas C, Müller M, McNeal , Lovy , Jaňa F, Bustos , Urra F, Smith N, Molgó J, Diehl JA, Ridky TW, Foskett JK. Selective Vulnerability of Cancer Cells by Inhibition of Ca(2+) Transfer from Endoplasmic Reticulum to Mitochondria. Cell Rep. 2016;14(10):2313-24.
  • F.A. Urra, M. Martínez-Cifuentes, H. Pessoa-Mahana, M. Pavani, J. Ferreira and R. Araya-Maturana. Ortho-carbonyl substituted hydroquinone is an anticancer agent that acts through the inhibition of mitochondrial bioenergetics and induces G2/M- phase arrest in mouse mammary adenocarcinoma TA3 Toxicol. Appl. Pharmacol. 2013;267(3):218-27
  • F.A. Urra, M. Córdova-Delgado, H. Pessoa-Mahana, O. Ramírez-Rodríguez, B. Weiss-López, J. Ferreira, and R. Araya-Maturana. Mitochondria: A Promising Target for Anticancer Alkaloids. Curr Top Med Chem. 2013;13(17):2171-83.