Team

Félix A. Urra, PhD

Félix A. Urra, PhD

Principal Investigator

I studied Pharmaceutical Chemistry, working as an undergraduate in the lab of Dr. Jorge Ferreira in mitochondrial bioenergetics. I then obtained a Ph.D. in Pharmacology and hold a postdoctoral fellowship at University of Chile. Currently, I am Assistant Professor at Faculty of Medicine (University of Chile), Principal Investigator of MPB Lab, Director of Chilean team of Snake Venom Research and Drug Discovery, and Co-founder and Editor-in-Chief of Chilean Bulletin of Herpetology.

My research has been focused on studying the role of calcium and non-essential amino acids in the rewiring of mitochondrial bioenergetics during the proliferation and migration of cancer cells. Moreover, I am interested in identifying new bioactive compounds with mitochondrial action, exploring synthetic compounds or toxins from snake and amphibian´s secretions. For this, we evaluate the cellular metabolism in real-time using XFe96 technology, RNA-seq analysis, metabolomics, and microscopy-based methods.

Sebastián Fuentes-Retamal

Sebastián Fuentes-Retamal

Postdoctoral fellow

Ph.D. in Pharmacology, University of Chile. Working on the role of alpha-KGDH in triple-negative breast cancer cell migration.

Karen Dubois-Camacho

Karen Dubois-Camacho

Postdoctoral fellow

PhD in Biomedical Sciences, University of Chile. Working on the targeting of mitochondrial bioenergetics to alleviate inflammation in colitis-associated macrophages

Juan Pablo Millas Vargas

Juan Pablo Millas Vargas

PhD student

Chemist, PhD student in Sciences Of Bioactive Products, University of Talca. Working on synthesis of bioactive mitochondria-targeted compounds as antiplatelet and anticancer agents.

Hector L. Montecino Garrido

Hector L. Montecino Garrido

PhD student

Bioinformatics engineer, PhD student in Biomedical Sciences, University of Talca. Working on the characterization of antiplatelet activity from derivatives of gentisic acid that inhibits mitochondrial bioenergetics.

Francisco Fuentealba

Francisco Fuentealba

PhD student

PhD student in Biomedical Sciences, University of Chile. Working on mechanisms of adaptation of mitochondrial bioenergetics induced by chemotherapeutics in breast cancer cells.

Yarcely Rodriguez

Yarcely Rodriguez

PhD student

PhD student in Sciences of Bioactive Products, University of Talca, studying new small molecules as Complex I inhibitors with migrastatic effects in breast cancer cells.

Charlotte Palominos

Charlotte Palominos

Master student

Teacher of Secondary Education in Biology and Natural Science, Metropolitan University of Educational Sciences. Master student in Biological Sciences, University of Chile. Studying the importance of tricarboxylic acid cycle enzyme in vulnerability to cell death induced by mitochondrial dysfunction in lung cancer stem cell.

Yarela Herrera

Yarela Herrera

Undergraduate student

Biology student from University of Concepción, studying the characterization of venom delivery system and the identification of toxins’s coding genes from Tachymenis chilensis.

Pablo Correa

Pablo Correa

Undergraduate student

Medicine student, University of Chile. Focused on mitochondrial metabolism in metastasis.

Sofia Burgos

Sofia Burgos

Undergraduate student

Medical student from University of Chile, studying the anticancer effect of new metabolic inhibitors.

Camila López-Torres

Camila López-Torres

Research assistant

Biochemist, University of Chile.