Félix A. Urra, PhD
I studied Pharmaceutical Chemistry, working as an undergraduate in the lab of Dr. Jorge Ferreira in mitochondrial bioenergetics. I then obtained a Ph.D. in Pharmacology and hold a postdoctoral fellowship at University of Chile. Currently, I am Assistant Professor at Faculty of Medicine (University of Chile), Principal Investigator of MPB Lab, Director of Chilean team of Snake Venom Research and Drug Discovery, and Co-founder and Editor-in-Chief of Chilean Bulletin of Herpetology.
My research has been focused on studying the role of calcium and non-essential amino acids in the rewiring of mitochondrial bioenergetics during the proliferation and migration of cancer cells. Moreover, I am interested in identifying new bioactive compounds with mitochondrial action, exploring synthetic compounds or toxins from snake and amphibian´s secretions. For this, we evaluate the cellular metabolism in real-time using XFe96 technology, RNA-seq analysis, metabolomics, and microscopy-based methods.
Ph.D. in Pharmacology, University of Chile. Working on the role of alpha-KGDH in triple-negative breast cancer cell migration.
PhD in Biomedical Sciences, University of Chile. Working on the targeting of mitochondrial bioenergetics to alleviate inflammation in colitis-associated macrophages
Juan Pablo Millas Vargas
Chemist, PhD student in Sciences Of Bioactive Products, University of Talca. Working on synthesis of bioactive mitochondria-targeted compounds as antiplatelet and anticancer agents.
Hector L. Montecino Garrido
Bioinformatics engineer, PhD student in Biomedical Sciences, University of Talca. Working on the characterization of antiplatelet activity from derivatives of gentisic acid that inhibits mitochondrial bioenergetics.
PhD student in Sciences of Bioactive Products, University of Talca, studying new small molecules as Complex I inhibitors with migrastatic effects in breast cancer cells.
PhD student in Pharmacology, University of Chile. Working on mechanisms of adaptation of mitochondrial bioenergetics induced by chemotherapeutics in breast cancer cells.
PhD student in Biomedical Sciences, University of Chile. Working on transcriptomics of venom gland of rear-fanged snakes and molecular mechanism of action of toxins.
Master student in Biological Sciences, University of Chile. Studying the importance of tricarboxylic acid cycle enzyme in vulnerability to cell death induced by mitochondrial dysfunction in lung cancer stem cell.
Ana Belén Tenorio
Master student in Biological Sciences, University of Chile. Studying the effect of sv-phospholipases A2 on mitochondrial respiration of cancer cells
Studying the effect of quinones on mitochondrial morphology and bioenergetics of breast cancer cells
Medicine student, University of Chile. Focused on mitochondrial metabolism in metastasis.
Medical student from University of Chile, studying the anticancer effect of new metabolic inhibitors.